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Systematic name YDR323C
Gene name PEP7
Aliases VAC1, VPL21, VPS19, VPT19
Feature type ORF, Verified
Coordinates Chr IV:1114027..1112480
Primary SGDID S000002731

Description of YDR323C: Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance[1][2][3][4][5][6]


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  1. Burd CG, et al. (1997) A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast. Mol Biol Cell 8(6):1089-104 SGD PMID 9201718
  2. Conradt B, et al. (1992) In vitro reactions of vacuole inheritance in Saccharomyces cerevisiae. J Cell Biol 119(6):1469-79 SGD PMID 1334958
  3. Peterson MR, et al. (1999) Vac1p coordinates Rab and phosphatidylinositol 3-kinase signaling in Vps45p-dependent vesicle docking/fusion at the endosome. Curr Biol 9(3):159-62 SGD PMID 10021387
  4. Tall GG, et al. (1999) The phosphatidylinositol 3-phosphate binding protein Vac1p interacts with a Rab GTPase and a Sec1p homologue to facilitate vesicle-mediated vacuolar protein sorting. Mol Biol Cell 10(6):1873-89 SGD PMID 10359603
  5. Webb GC, et al. (1997) Pep7p provides a novel protein that functions in vesicle-mediated transport between the yeast Golgi and endosome. Mol Biol Cell 8(5):871-95 SGD PMID 9168472
  6. Weisman LS and Wickner W (1992) Molecular characterization of VAC1, a gene required for vacuole inheritance and vacuole protein sorting. J Biol Chem 267(1):618-23 SGD PMID 1730622

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