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Systematic name YDR265W
Gene name PEX10
Aliases PAS4
Feature type ORF, Verified
Coordinates Chr IV:998864..999877
Primary SGDID S000002673

Description of YDR265W: Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders[1][2][3][4][5][6]


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Protein Details

Other Protein Details

Other Topic: Homology

Homology was found, at the sequence and domain-composition level, between several components of the Peroxisomal protein import machinery and components of the Endoplasmic Reticulum Associated Decay (ERAD) pathway. This suggests a common evolutionary origin for both systems and a similar mechanism of action. The homology relationships can be stablished between Pex1,Pex6 and cdc48; Pex2 and Hrd1; Pex4 and Ubc1; and Pex5 and Hrd3. [7] [8]



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  1. Albertini M, et al. (2001) Pex12p of Saccharomyces cerevisiae is a component of a multi-protein complex essential for peroxisomal matrix protein import. Eur J Cell Biol 80(4):257-70 SGD PMID 11370741
  2. Eckert JH and Johnsson N (2003) Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisome. J Cell Sci 116(Pt 17):3623-34 SGD PMID 12876220
  3. Platta HW, et al. (2009) Pex2 and pex12 function as protein-ubiquitin ligases in peroxisomal protein import. Mol Cell Biol 29(20):5505-16 SGD PMID 19687296
  4. Purdue PE and Lazarow PB (2001) Peroxisome biogenesis. Annu Rev Cell Dev Biol 17:701-52 SGD PMID 11687502
  5. Warren DS, et al. (1998) Identification of PEX10, the gene defective in complementation group 7 of the peroxisome-biogenesis disorders. Am J Hum Genet 63(2):347-59 SGD PMID 9683594
  6. Williams C, et al. (2008) Pex10p functions as an E3 ligase for the Ubc4p-dependent ubiquitination of Pex5p. Biochem Biophys Res Commun 374(4):620-4 SGD PMID 18644345
  7. Gabaldon T, et al. (2006) Origin and evolution of the peroxisomal proteome. Biol Direct 1():8 SGD PMID 16556314
  8. submitted by Toni Gabaldon on 2006-04-12

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