YDR207C
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| Systematic name | YDR207C |
| Gene name | UME6 |
| Aliases | CAR80, NIM2, RIM16 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:867522..865012 |
| Primary SGDID | S000002615 |
Description of YDR207C: Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p[1][2][3][4][5][6][7][8]
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References
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- ↑ Anderson SF, et al. (1995) UME6, a negative regulator of meiosis in Saccharomyces cerevisiae, contains a C-terminal Zn2Cys6 binuclear cluster that binds the URS1 DNA sequence in a zinc-dependent manner. Protein Sci 4(9):1832-43 SGD PMID 8528081
- ↑ Bowdish KS and Mitchell AP (1993) Bipartite structure of an early meiotic upstream activation sequence from Saccharomyces cerevisiae. Mol Cell Biol 13(4):2172-81 SGD PMID 8455605
- ↑ Elkhaimi M, et al. (2000) Combinatorial regulation of phospholipid biosynthetic gene expression by the UME6, SIN3 and RPD3 genes. Nucleic Acids Res 28(16):3160-7 SGD PMID 10931932
- ↑ Malathi K, et al. (1997) Interaction of yeast repressor-activator protein Ume6p with glycogen synthase kinase 3 homolog Rim11p. Mol Cell Biol 17(12):7230-6 SGD PMID 9372955
- ↑ Messenguy F, et al. (2000) In Saccharomyces cerevisiae, expression of arginine catabolic genes CAR1 and CAR2 in response to exogenous nitrogen availability is mediated by the Ume6 (CargRI)-Sin3 (CargRII)-Rpd3 (CargRIII) complex. J Bacteriol 182(11):3158-64 SGD PMID 10809695
- ↑ Steber CM and Esposito RE (1995) UME6 is a central component of a developmental regulatory switch controlling meiosis-specific gene expression. Proc Natl Acad Sci U S A 92(26):12490-4 SGD PMID 8618927
- ↑ Strich R, et al. (1994) UME6 is a key regulator of nitrogen repression and meiotic development. Genes Dev 8(7):796-810 SGD PMID 7926768
- ↑ Williams RM, et al. (2002) The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast. Proc Natl Acad Sci U S A 99(21):13431-6 SGD PMID 12370439
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