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Systematic name YDR177W
Gene name UBC1
Feature type ORF, Verified
Coordinates Chr IV:816878..817525
Primary SGDID S000002584

Description of YDR177W: Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response[1][2][3][4]


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  1. Friedlander R, et al. (2000) A regulatory link between ER-associated protein degradation and the unfolded-protein response. Nat Cell Biol 2(7):379-84 SGD PMID 10878801
  2. Seufert W and Jentsch S (1991) Yeast ubiquitin-conjugating enzymes involved in selective protein degradation are essential for cell viability. Acta Biol Hung 42(1-3):27-37 SGD PMID 1844315
  3. Seufert W, et al. (1990) UBC1 encodes a novel member of an essential subfamily of yeast ubiquitin-conjugating enzymes involved in protein degradation. EMBO J 9(13):4535-41 SGD PMID 2265617
  4. Shieh HL, et al. (2001) Biochemical analysis of fructose-1,6-bisphosphatase import into vacuole import and degradation vesicles reveals a role for UBC1 in vesicle biogenesis. J Biol Chem 276(13):10398-406 SGD PMID 11134048

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