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Systematic name YDR171W
Gene name HSP42
Feature type ORF, Verified
Coordinates Chr IV:806621..807748
Primary SGDID S000002578

Description of YDR171W: Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock[1][2][3][4]


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  1. Gu J, et al. (1997) Small heat shock protein suppression of Vpr-induced cytoskeletal defects in budding yeast. Mol Cell Biol 17(7):4033-42 SGD PMID 9199338
  2. Haslbeck M, et al. (2004) Hsp42 is the general small heat shock protein in the cytosol of Saccharomyces cerevisiae. EMBO J 23(3):638-49 SGD PMID 14749732
  3. Trotter EW, et al. (2002) Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiae. J Biol Chem 277(47):44817-25 SGD PMID 12239211
  4. Wotton D, et al. (1996) Multimerization of Hsp42p, a novel heat shock protein of Saccharomyces cerevisiae, is dependent on a conserved carboxyl-terminal sequence. J Biol Chem 271(5):2717-23 SGD PMID 8576246

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