YDR159W
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| Systematic name | YDR159W |
| Gene name | SAC3 |
| Aliases | LEP1 |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:771877..775782 |
| Primary SGDID | S000002566 |
Description of YDR159W: Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)[1][2][3][4][5][6][7][8]
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References
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- ↑ Chekanova JA, et al. (2008) Sus1, Sac3, and Thp1 mediate post-transcriptional tethering of active genes to the nuclear rim as well as to non-nascent mRNP. RNA 14(1):66-77 SGD PMID 18003937
- ↑ Fischer T, et al. (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J 21(21):5843-52 SGD PMID 12411502
- ↑ Gallardo M, et al. (2003) Nab2p and the Thp1p-Sac3p complex functionally interact at the interface between transcription and mRNA metabolism. J Biol Chem 278(26):24225-32 SGD PMID 12702719
- ↑ Lei EP, et al. (2003) Sac3 is an mRNA export factor that localizes to cytoplasmic fibrils of nuclear pore complex. Mol Biol Cell 14(3):836-47 SGD PMID 12631707
- ↑ Li Z, et al. (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213 SGD PMID 19806183
- ↑ Novick P, et al. (1989) Suppressors of yeast actin mutations. Genetics 121(4):659-74 SGD PMID 2656401
- ↑ Phimsen S, et al. (2012) Selective cell death of p53-insufficient cancer cells is induced by knockdown of the mRNA export molecule GANP. Apoptosis () SGD PMID 22395445
- ↑ Tous C, et al. (2011) A novel assay identifies transcript elongation roles for the Nup84 complex and RNA processing factors. EMBO J 30(10):1953-64 SGD PMID 21478823
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