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Systematic name YDR130C
Gene name FIN1
Feature type ORF, Verified
Coordinates Chr IV:716622..715747
Primary SGDID S000002537

Description of YDR130C: Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation[1][2][3][4][5]


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Protein Details

Protein Modification

Modification(s): Glycosylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [6] [7]



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  1. Akiyoshi B, et al. (2009) Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunit. Genes Dev 23(24):2887-99 SGD PMID 19948764
  2. Mayordomo I and Sanz P (2002) The Saccharomyces cerevisiae 14-3-3 protein Bmh2 is required for regulation of the phosphorylation status of Fin1, a novel intermediate filament protein. Biochem J 365(Pt 1):51-6 SGD PMID 11931638
  3. Woodbury EL and Morgan DO (2007) The Role of Self-association in Fin1 Function on the Mitotic Spindle. J Biol Chem 282(44):32138-43 SGD PMID 17804403
  4. van Hemert MJ, et al. (2002) The Saccharomyces cerevisiae Fin1 protein forms cell cycle-specific filaments between spindle pole bodies. Proc Natl Acad Sci U S A 99(8):5390-3 SGD PMID 11929974
  5. van Hemert MJ, et al. (2003) Self-association of the spindle pole body-related intermediate filament protein Fin1p and its phosphorylation-dependent interaction with 14-3-3 proteins in yeast. J Biol Chem 278(17):15049-55 SGD PMID 12551942
  6. Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  7. submitted by Jeff Ubersax on 2004-01-21

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