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Systematic name YDR069C
Gene name DOA4
Aliases DOS1, MUT4, NPI2, SSV7, UBP4
Feature type ORF, Verified
Coordinates Chr IV:587719..584939
Primary SGDID S000002476

Description of YDR069C: Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole[1][2][3]


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  1. Amerik AY, et al. (2000) The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways. Mol Biol Cell 11(10):3365-80 SGD PMID 11029042
  2. Singer JD, et al. (1996) Coordinating DNA replication to produce one copy of the genome requires genes that act in ubiquitin metabolism. Mol Cell Biol 16(4):1356-66 SGD PMID 8657109
  3. Swaminathan S, et al. (1999) The Doa4 deubiquitinating enzyme is required for ubiquitin homeostasis in yeast. Mol Biol Cell 10(8):2583-94 SGD PMID 10436014

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