YDR050C
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| Systematic name | YDR050C |
| Gene name | TPI1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:556472..555726 |
| Primary SGDID | S000002457 |
Description of YDR050C: Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease[1][2][3][4][5]
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References
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- ↑ Alber T and Kawasaki G (1982) Nucleotide sequence of the triose phosphate isomerase gene of Saccharomyces cerevisiae. J Mol Appl Genet 1(5):419-34 SGD PMID 6759603
- ↑ Gruning NM, et al. (2011) Pyruvate Kinase Triggers a Metabolic Feedback Loop that Controls Redox Metabolism in Respiring Cells. Cell Metab 14(3):415-27 SGD PMID 21907146
- ↑ Krieger K and Ernst JF (1994) Iron regulation of triosephosphate isomerase transcript stability in the yeast Saccharomyces cerevisiae. Microbiology 140 ( Pt 5):1079-84 SGD PMID 8025673
- ↑ Rodriguez-Almazan C, et al. (2008) Structural basis of human triosephosphate isomerase deficiency: mutation E104D is related to alterations of a conserved water network at the dimer interface. J Biol Chem 283(34):23254-63 SGD PMID 18562316
- ↑ Scott EW and Baker HV (1993) Concerted action of the transcriptional activators REB1, RAP1, and GCR1 in the high-level expression of the glycolytic gene TPI. Mol Cell Biol 13(1):543-50 SGD PMID 8417350
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