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Systematic name YDR044W
Gene name HEM13
Feature type ORF, Verified
Coordinates Chr IV:546642..547628
Primary SGDID S000002451

Description of YDR044W: Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)[1][2][3][4]


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  1. Amillet JM, et al. (1995) Positive and negative elements involved in the differential regulation by heme and oxygen of the HEM13 gene (coproporphyrinogen oxidase) in Saccharomyces cerevisiae. Curr Genet 28(6):503-11 SGD PMID 8593679
  2. Keng T (1992) HAP1 and ROX1 form a regulatory pathway in the repression of HEM13 transcription in Saccharomyces cerevisiae. Mol Cell Biol 12(6):2616-23 SGD PMID 1588959
  3. Urban-Grimal D and Labbe-Bois R (1981) Genetic and biochemical characterization of mutants of Saccharomyces cerevisiae blocked in six different steps of heme biosynthesis. Mol Gen Genet 183(1):85-92 SGD PMID 7035824
  4. Zagorec M, et al. (1988) Isolation, sequence, and regulation by oxygen of the yeast HEM13 gene coding for coproporphyrinogen oxidase. J Biol Chem 263(20):9718-24 SGD PMID 2838478

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