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Systematic name YDL207W
Gene name GLE1
Aliases BRR3, RSS1
Feature type ORF, Verified
Coordinates Chr IV:88248..89864
Primary SGDID S000002366

Description of YDL207W: Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear pore complex during mRNA export[1][2][3][4][5]


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  1. Alcazar-Roman AR, et al. (2006) Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export. Nat Cell Biol 8(7):711-6 SGD PMID 16783363
  2. Del Priore V, et al. (1996) The product of the Saccharomyces cerevisiae RSS1 gene, identified as a high-copy suppressor of the rat7-1 temperature-sensitive allele of the RAT7/NUP159 nucleoporin, is required for efficient mRNA export. Mol Biol Cell 7(10):1601-21 SGD PMID 8898365
  3. Hurwitz ME, et al. (1998) Two yeast nuclear pore complex proteins involved in mRNA export form a cytoplasmically oriented subcomplex. Proc Natl Acad Sci U S A 95(19):11241-5 SGD PMID 9736720
  4. Murphy R and Wente SR (1996) An RNA-export mediator with an essential nuclear export signal. Nature 383(6598):357-60 SGD PMID 8848052
  5. Noble KN, et al. (2011) The Dbp5 cycle at the nuclear pore complex during mRNA export II: nucleotide cycling and mRNP remodeling by Dbp5 are controlled by Nup159 and Gle1. Genes Dev 25(10):1065-77 SGD PMID 21576266

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