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Systematic name YDL168W
Gene name SFA1
Aliases ADH5
Feature type ORF, Verified
Coordinates Chr IV:159604..160764
Primary SGDID S000002327

Description of YDL168W: Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p[1][2][3]


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  1. Grey M, et al. (1996) Overexpression of ADH1 confers hyper-resistance to formaldehyde in Saccharomyces cerevisiae. Curr Genet 29(5):437-40 SGD PMID 8625422
  2. Rep M, et al. (2001) The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage. Mol Microbiol 40(5):1067-83 SGD PMID 11401713
  3. Wehner EP, et al. (1993) Molecular structure and genetic regulation of SFA, a gene responsible for resistance to formaldehyde in Saccharomyces cerevisiae, and characterization of its protein product. Mol Gen Genet 237(3):351-8 SGD PMID 8483449

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