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Systematic name YDL133W
Gene name SRF1
Feature type ORF, Verified
Coordinates Chr IV:222427..223740
Primary SGDID S000002291

Description of YDL133W: Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients[1][2]


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  1. Fisk DG, et al. (2006) Saccharomyces cerevisiae S288C genome annotation: a working hypothesis. Yeast 23(12):857-65 SGD PMID 17001629
  2. Kennedy MA, et al. (2011) Srf1 is a novel regulator of phospholipase d activity and is essential to buffer the toxic effects of c16:0 platelet activating factor. PLoS Genet 7(2):e1001299 SGD PMID 21347278

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