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Systematic name YDL126C
Gene name CDC48
Feature type ORF, Verified
Coordinates Chr IV:238664..236157
Primary SGDID S000002284

Description of YDL126C: AAA ATPase involved in multiple processes; subunit of a polyubiquitin-selective segregase complex involved in ERAD, cell wall integrity during heat stress and mitotic spindle disassembly; subunit of a complex involved in mitochondria-associated degradation; role in mobilizing membrane bound transcription factors by regulated ubiquitin/proteasome-dependent processing; roles in macroautophagy, PMN, ribophagy, and homotypic ER membrane fusion; functional ortholog of p97/VCP[1][2][3][4][5][6][7][8]


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  1. Cao K, et al. (2003) The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis. Cell 115(3):355-67 SGD PMID 14636562
  2. Heo JM, et al. (2010) A stress-responsive system for mitochondrial protein degradation. Mol Cell 40(3):465-80 SGD PMID 21070972
  3. Hsieh MT and Chen RH (2011) Cdc48 and Cofactors Npl4-Ufd1 Are Important for G1 Progression during Heat Stress by Maintaining Cell Wall Integrity in Saccharomyces cerevisiae. PLoS One 6(4):e18988 SGD PMID 21526151
  4. Ossareh-Nazari B, et al. (2010) Cdc48 and Ufd3, new partners of the ubiquitin protease Ubp3, are required for ribophagy. EMBO Rep 11(7):548-54 SGD PMID 20508643
  5. Rape M, et al. (2001) Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone. Cell 107(5):667-77 SGD PMID 11733065
  6. Shcherbik N and Haines DS (2007) Cdc48p(Npl4p/Ufd1p) binds and segregates membrane-anchored/tethered complexes via a polyubiquitin signal present on the anchors. Mol Cell 25(3):385-97 SGD PMID 17289586
  7. Stolz A, et al. (2011) Cdc48: a power machine in protein degradation. Trends Biochem Sci 36(10):515-23 SGD PMID 21741246
  8. Ye Y, et al. (2003) Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains. J Cell Biol 162(1):71-84 SGD PMID 12847084

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