YDL074C
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| Systematic name | YDL074C |
| Gene name | BRE1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr IV:326149..324047 |
| Primary SGDID | S000002232 |
Description of YDL074C: E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control[1][2][3]
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References
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- ↑ Kim J and Roeder RG (2009) Direct Bre1-Paf1 Complex Interactions and RING Finger-independent Bre1-Rad6 Interactions Mediate Histone H2B Ubiquitylation in Yeast. J Biol Chem 284(31):20582-92 SGD PMID 19531475
- ↑ Wood A, et al. (2003) Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell 11(1):267-74 SGD PMID 12535539
- ↑ Wysocki R, et al. (2005) Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9. Mol Cell Biol 25(19):8430-43 SGD PMID 16166626
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