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Systematic name YCR081W
Gene name SRB8
Aliases GIG1, MED12, NUT6, SSN5, YCR080W
Feature type ORF, Verified
Coordinates Chr III:254371..258654
Primary SGDID S000000677

Description of YCR081W: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression[1][2][3]


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  1. Balciunas D and Ronne H (1995) Three subunits of the RNA polymerase II mediator complex are involved in glucose repression. Nucleic Acids Res 23(21):4421-5 SGD PMID 7501465
  2. Hengartner CJ, et al. (1995) Association of an activator with an RNA polymerase II holoenzyme. Genes Dev 9(8):897-910 SGD PMID 7774808
  3. Kornberg RD (2005) Mediator and the mechanism of transcriptional activation. Trends Biochem Sci 30(5):235-9 SGD PMID 15896740

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