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Systematic name YCL067C
Gene name HMLALPHA2
Aliases ALPHA2
Feature type ORF, silenced_gene,Verified
Coordinates Chr III:13018..12386
Primary SGDID S000000572

Description of YCL067C: Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression[1][2][3][4][5][6][7][8][9]


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  1. Goutte C and Johnson AD (1988) a1 protein alters the DNA binding specificity of alpha 2 repressor. Cell 52(6):875-82 SGD PMID 3127056
  2. Goutte C and Johnson AD (1993) Yeast a1 and alpha 2 homeodomain proteins form a DNA-binding activity with properties distinct from those of either protein. J Mol Biol 233(3):359-71 SGD PMID 8411150
  3. Goutte C and Johnson AD (1994) Recognition of a DNA operator by a dimer composed of two different homeodomain proteins. EMBO J 13(6):1434-42 SGD PMID 7907979
  4. Herskowitz I (1989) A regulatory hierarchy for cell specialization in yeast. Nature 342(6251):749-57 SGD PMID 2513489
  5. Herskowitz I, et al. (1992) Mating-type determination and mating-type interconversion in Saccharomyces cerevisiae. Pp. 583-656 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press SGD PMID
  6. Murphy MR, et al. (1993) DNA-protein interactions at the S.cerevisiae alpha 2 operator in vivo. Nucleic Acids Res 21(14):3295-300 SGD PMID 8341604
  7. Smith DL and Johnson AD (1992) A molecular mechanism for combinatorial control in yeast: MCM1 protein sets the spacing and orientation of the homeodomains of an alpha 2 dimer. Cell 68(1):133-42 SGD PMID 1732062
  8. Vershon AK and Johnson AD (1993) A short, disordered protein region mediates interactions between the homeodomain of the yeast alpha 2 protein and the MCM1 protein. Cell 72(1):105-12 SGD PMID 8422672
  9. Zhong H, et al. (1999) Identification of target sites of the alpha2-Mcm1 repressor complex in the yeast genome. Genome Res 9(11):1040-7 SGD PMID 10568744

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