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Systematic name YCL066W
Gene name HMLALPHA1
Aliases ALPHA1
Feature type ORF, silenced_gene,Verified
Coordinates Chr III:13282..13809
Primary SGDID S000000571

Description of YCL066W: Silenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression[1][2][3][4][5][6]


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  1. Bender A and Sprague GF Jr (1987) MAT alpha 1 protein, a yeast transcription activator, binds synergistically with a second protein to a set of cell-type-specific genes. Cell 50(5):681-91 SGD PMID 3304657
  2. Grayhack EJ (1992) The yeast alpha 1 and MCM1 proteins bind a single strand of their duplex DNA recognition site. Mol Cell Biol 12(8):3573-82 SGD PMID 1630462
  3. Herskowitz I (1989) A regulatory hierarchy for cell specialization in yeast. Nature 342(6251):749-57 SGD PMID 2513489
  4. Herskowitz I, et al. (1992) Mating-type determination and mating-type interconversion in Saccharomyces cerevisiae. Pp. 583-656 in The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression, edited by Jones EW, Pringle JR and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press SGD PMID
  5. Mead J, et al. (2002) Interactions of the Mcm1 MADS box protein with cofactors that regulate mating in yeast. Mol Cell Biol 22(13):4607-21 SGD PMID 12052870
  6. Tan S, et al. (1988) Interactions of purified transcription factors: binding of yeast MAT alpha 1 and PRTF to cell type-specific, upstream activating sequences. EMBO J 7(13):4255-64 SGD PMID 2854061

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