YCL064C
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| Systematic name | YCL064C |
| Gene name | CHA1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr III:16880..15798 |
| Primary SGDID | S000000569 |
Description of YCL064C: Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine[1][2]
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Contents
Community Commentary
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DNA and RNA Details
Other DNA and RNA Details
Other Topic: Gene regulation
Loss of the histone H3 amino terminus (but not that of H4) causes constitutive activation and chromatin remodeling of CHA1. The constitutive activation requires the activator Cha4p, which is bound to the promoter in wild type yeast under both repressed and activating conditions. [3] [4]
Other Topic: Chromatin structure
TATA element is nucleosomal in repressed promoter; nucleosome is disrupted upon activation. This remodeling does not require SWI/SNF or Gcn5p and may occur independently of TBP recruitment. [5] [4]
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References
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- ↑ Bornaes C, et al. (1993) A regulatory element in the CHA1 promoter which confers inducibility by serine and threonine on Saccharomyces cerevisiae genes. Mol Cell Biol 13(12):7604-11 SGD PMID 8246977
- ↑ Petersen JG, et al. (1988) Molecular genetics of serine and threonine catabolism in Saccharomyces cerevisiae. Genetics 119(3):527-34 SGD PMID 2841185
- ↑ Sabet N, et al. (2003) Global and specific transcriptional repression by the histone H3 amino terminus in yeast. Proc Natl Acad Sci U S A 100(7):4084-9 SGD PMID 12649325
- ↑ 4.0 4.1 submitted by Randall Morse on 2004-12-03
- ↑ Moreira JM and Holmberg S (1998) Nucleosome structure of the yeast CHA1 promoter: analysis of activation-dependent chromatin remodeling of an RNA-polymerase-II-transcribed gene in TBP and RNA pol II mutants defective in vivo in response to acidic activators. EMBO J 17(20):6028-38 SGD PMID 9774346
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