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Systematic name YCL057W
Gene name PRD1
Feature type ORF, Verified
Coordinates Chr III:24768..26906
Primary SGDID S000000562

Description of YCL057W: Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins[1][2][3]


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  1. Buchler M, et al. (1994) Proteinase yscD (oligopeptidase yscD). Structure, function and relationship of the yeast enzyme with mammalian thimet oligopeptidase (metalloendopeptidase, EP 24.15). Eur J Biochem 219(1-2):627-39 SGD PMID 8307027
  2. Hrycyna CA and Clarke S (1993) Purification and characterization of a novel metalloendopeptidase from Saccharomyces cerevisiae. Biochemistry 32(42):11293-301 SGD PMID 8218194
  3. Kambacheld M, et al. (2005) Role of the novel metallopeptidase Mop112 and saccharolysin for the complete degradation of proteins residing in different subcompartments of mitochondria. J Biol Chem 280(20):20132-9 SGD PMID 15772085

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