YCL017C

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Systematic name YCL017C
Gene name NFS1
Aliases SPL1
Feature type ORF, Verified
Coordinates Chr III:94270..92777
Primary SGDID S000000522


Description of YCL017C: Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria[1][2][3]




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References

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  1. Kispal G, et al. (1999) The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins. EMBO J 18(14):3981-9 SGD PMID 10406803
  2. Muhlenhoff U, et al. (2004) Functional characterization of the eukaryotic cysteine desulfurase Nfs1p from Saccharomyces cerevisiae. J Biol Chem 279(35):36906-15 SGD PMID 15220327
  3. Nakai Y, et al. (2004) Yeast Nfs1p is involved in thio-modification of both mitochondrial and cytoplasmic tRNAs. J Biol Chem 279(13):12363-8 SGD PMID 14722066

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