YCL016C

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Systematic name YCL016C
Gene name DCC1
Aliases
Feature type ORF, Verified
Coordinates Chr III:95763..94621
Primary SGDID S000000521


Description of YCL016C: Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance[1][2]




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Community Commentary

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Alleles, Strains, and Phenotypes

Complete Deletion

Phenotype(s): Viable

Deletion mutant is defective in telomere positioning to nuclear periphery. [3] [4]


Multiple Knockout Strains

Together with: RAD9, CTF8
Phenotype(s): Viable

dcc1 rad9 double deletion strain is defective in phosphorylation of Rad53p and shows higher sensitivity to HU and MMS than WT and single mutant strains. [5] [4]





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References

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  1. Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63 SGD PMID 15161972
  2. Mayer ML, et al. (2001) Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. Mol Cell 7(5):959-70 SGD PMID 11389843
  3. Hiraga S, et al. (2006) The Ctf18 RFC-like complex positions yeast telomeres but does not specify their replication time. EMBO J 25(7):1505-14 SGD PMID 16525505
  4. 4.0 4.1 submitted by Shin-ichiro Hiraga on 2006-06-20
  5. Pan X, et al. (2006) A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell 124(5):1069-81 SGD PMID 16487579

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