YBR240C
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| Systematic name | YBR240C |
| Gene name | THI2 |
| Aliases | PHO6, phoF |
| Feature type | ORF, Verified |
| Coordinates | Chr II:701842..700490 |
| Primary SGDID | S000000444 |
Description of YBR240C: Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate demand, possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type[1][2][3][4][5][6]
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References
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- ↑ Akache B, et al. (2001) Phenotypic analysis of genes encoding yeast zinc cluster proteins. Nucleic Acids Res 29(10):2181-90 SGD PMID 11353088
- ↑ Mojzita D and Hohmann S (2006) Pdc2 coordinates expression of the THI regulon in the yeast Saccharomyces cerevisiae. Mol Genet Genomics 276(2):147-61 SGD PMID 16850348
- ↑ Nishimura H, et al. (1992) Cloning and characteristics of a positive regulatory gene, THI2 (PHO6), of thiamin biosynthesis in Saccharomyces cerevisiae. FEBS Lett 297(1-2):155-8 SGD PMID 1551422
- ↑ Nosaka K, et al. (1994) Isolation and characterization of the THI6 gene encoding a bifunctional thiamin-phosphate pyrophosphorylase/hydroxyethylthiazole kinase from Saccharomyces cerevisiae. J Biol Chem 269(48):30510-6 SGD PMID 7982968
- ↑ Nosaka K, et al. (2005) Genetic regulation mediated by thiamin pyrophosphate-binding motif in Saccharomyces cerevisiae. Mol Microbiol 58(2):467-79 SGD PMID 16194233
- ↑ Nosaka K, et al. (2008) Thiamin-dependent transactivation activity of PDC2 in Saccharomyces cerevisiae. FEBS Lett 582(29):3991-6 SGD PMID 19013460
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