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Systematic name YBR143C
Gene name SUP45
Aliases SAL4, SUP1, SUP47
Feature type ORF, Verified
Coordinates Chr II:532182..530869
Primary SGDID S000000347

Description of YBR143C: Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin[1][2][3][4][5]


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  1. Heurgue-Hamard V, et al. (2006) The Zinc Finger Protein Ynr046w Is Plurifunctional and a Component of the eRF1 Methyltransferase in Yeast. J Biol Chem 281(47):36140-8 SGD PMID 17008308
  2. Himmelfarb HJ, et al. (1985) Isolation of the SUP45 omnipotent suppressor gene of Saccharomyces cerevisiae and characterization of its gene product. Mol Cell Biol 5(4):816-22 SGD PMID 3887137
  3. Stansfield I, et al. (1992) Ribosomal association of the yeast SAL4 (SUP45) gene product: implications for its role in translation fidelity and termination. Mol Microbiol 6(23):3469-78 SGD PMID 1474892
  4. Stansfield I, et al. (1995) The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae. EMBO J 14(17):4365-73 SGD PMID 7556078
  5. Studte P, et al. (2008) tRNA and protein methylase complexes mediate zymocin toxicity in yeast. Mol Microbiol 69(5):1266-77 SGD PMID 18657261

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