YBR036C

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Systematic name YBR036C
Gene name CSG2
Aliases CLS2
Feature type ORF, Verified
Coordinates Chr II:310313..309081
Primary SGDID S000000240


Description of YBR036C: Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations; protein abundance increases in response to DNA replication stress[1][2][3][4]




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References

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  1. Beeler T, et al. (1994) A novel protein, CSG2p, is required for Ca2+ regulation in Saccharomyces cerevisiae. J Biol Chem 269(10):7279-84 SGD PMID 8125941
  2. Stock SD, et al. (2000) Syringomycin E inhibition of Saccharomyces cerevisiae: requirement for biosynthesis of sphingolipids with very-long-chain fatty acids and mannose- and phosphoinositol-containing head groups. Antimicrob Agents Chemother 44(5):1174-80 SGD PMID 10770748
  3. Tanida I, et al. (1996) Yeast Cls2p/Csg2p localized on the endoplasmic reticulum membrane regulates a non-exchangeable intracellular Ca2+ pool cooperatively with calcineurin. FEBS Lett 379(1):38-42 SGD PMID 8566225
  4. Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.LID - 10.1038/ncb2549 [doi] Nat Cell Biol () SGD PMID 22842922

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