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Systematic name YBL079W
Gene name NUP170
Aliases NLE3
Feature type ORF, Verified
Coordinates Chr II:75259..79767
Primary SGDID S000000175

Description of YBL079W: Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC assembly and nucleocytoplasmic transport; has similarity to Nup157p; both Nup170p and NUP157p are similar to human Nup155p[1][2][3][4][5][6][7][8][9]


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Alleles, Strains, and Phenotypes

Complete Deletion

Phenotype(s): Loss of function (Null)

Null mutants display defects in chromosome transmission fidelity and kinetochore integrity [5] [10]



See Help:References on how to add references

  1. Aitchison JD, et al. (1995) Two novel related yeast nucleoporins Nup170p and Nup157p: complementation with the vertebrate homologue Nup155p and functional interactions with the yeast nuclear pore-membrane protein Pom152p. J Cell Biol 131(5):1133-48 SGD PMID 8522578
  2. Fernandez-Martinez J and Rout MP (2009) Nuclear pore complex biogenesis. Curr Opin Cell Biol 21(4):603-12 SGD PMID 19524430
  3. Iouk T, et al. (2002) The yeast nuclear pore complex functionally interacts with components of the spindle assembly checkpoint. J Cell Biol 159(5):807-19 SGD PMID 12473689
  4. Kenna MA, et al. (1996) Yeast N1e3p/Nup170p is required for normal stoichiometry of FG nucleoporins within the nuclear pore complex. Mol Cell Biol 16(5):2025-36 SGD PMID 8628268
  5. 5.0 5.1 Kerscher O, et al. (2001) Novel role for a Saccharomyces cerevisiae nucleoporin, Nup170p, in chromosome segregation. Genetics 157(4):1543-53 SGD PMID 11290711
  6. Makio T, et al. (2009) The nucleoporins Nup170p and Nup157p are essential for nuclear pore complex assembly. J Cell Biol 185(3):459-73 SGD PMID 19414608
  7. Meinema AC, et al. (2011) Long unfolded linkers facilitate membrane protein import through the nuclear pore complex. Science 333(6038):90-3 SGD PMID 21659568
  8. Rout MP, et al. (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51 SGD PMID 10684247
  9. Shulga N, et al. (2000) Yeast nucleoporins involved in passive nuclear envelope permeability. J Cell Biol 149(5):1027-38 SGD PMID 10831607
  10. submitted by Munira Basrai on 2005-07-29

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