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Systematic name YBL057C
Gene name PTH2
Feature type ORF, Verified
Coordinates Chr II:113427..112801
Primary SGDID S000000153

Description of YBL057C: One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth[1][2][3][4]


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  1. Fromant M, et al. (2003) Peptidyl-tRNA hydrolase from Sulfolobus solfataricus. Nucleic Acids Res 31(12):3227-35 SGD PMID 12799450
  2. Ishii T, et al. (2006) Yeast Pth2 is a UBL domain-binding protein that participates in the ubiquitin-proteasome pathway. EMBO J 25(23):5492-503 SGD PMID 17082762
  3. Rosas-Sandoval G, et al. (2002) Orthologs of a novel archaeal and of the bacterial peptidyl-tRNA hydrolase are nonessential in yeast. Proc Natl Acad Sci U S A 99(26):16707-12 SGD PMID 12475929
  4. Sickmann A, et al. (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12 SGD PMID 14576278

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