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Systematic name YBL052C
Gene name SAS3
Feature type ORF, Verified
Coordinates Chr II:121874..119379
Primary SGDID S000000148

Description of YBL052C: Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal[1][2][3][4]


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  1. Howe L, et al. (2001) Histone H3 specific acetyltransferases are essential for cell cycle progression. Genes Dev 15(23):3144-54 SGD PMID 11731478
  2. John S, et al. (2000) The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex. Genes Dev 14(10):1196-208 SGD PMID 10817755
  3. Reifsnyder C, et al. (1996) Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Nat Genet 14(1):42-9 SGD PMID 8782818
  4. Torres EM, et al. (2010) Identification of aneuploidy-tolerating mutations. Cell 143(1):71-83 SGD PMID 20850176

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