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Systematic name YBL050W
Gene name SEC17
Aliases RNS3
Feature type ORF, Verified
Coordinates Chr II:125125..126119
Primary SGDID S000000146

Description of YBL050W: Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP[1][2][3][4][5]


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  1. Griff IC, et al. (1992) The yeast SEC17 gene product is functionally equivalent to mammalian alpha-SNAP protein. J Biol Chem 267(17):12106-15 SGD PMID 1601878
  2. Ishihara N, et al. (2001) Autophagosome requires specific early Sec proteins for its formation and NSF/SNARE for vacuolar fusion. Mol Biol Cell 12(11):3690-702 SGD PMID 11694599
  3. Mayer A, et al. (1996) Sec18p (NSF)-driven release of Sec17p (alpha-SNAP) can precede docking and fusion of yeast vacuoles. Cell 85(1):83-94 SGD PMID 8620540
  4. Sogaard M, et al. (1994) A rab protein is required for the assembly of SNARE complexes in the docking of transport vesicles. Cell 78(6):937-48 SGD PMID 7923363
  5. Steel GJ, et al. (1999) Biochemical analysis of the Saccharomyces cerevisiae SEC18 gene product: implications for the molecular mechanism of membrane fusion. Biochemistry 38(24):7764-72 SGD PMID 10387016

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