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Systematic name YBL016W
Gene name FUS3
Aliases DAC2
Feature type ORF, Verified
Coordinates Chr II:192451..193512
Primary SGDID S000000112

Description of YBL016W: Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation[1][2][3][4][5][6]


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  1. Bao MZ, et al. (2004) Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast. Cell 119(7):991-1000 SGD PMID 15620357
  2. Breitkreutz A and Tyers M (2002) MAPK signaling specificity: it takes two to tango. Trends Cell Biol 12(6):254-7 SGD PMID 12074884
  3. Elion EA, et al. (1993) FUS3 phosphorylates multiple components of the mating signal transduction cascade: evidence for STE12 and FAR1. Mol Biol Cell 4(5):495-510 SGD PMID 8334305
  4. Garrison TR, et al. (1999) Feedback phosphorylation of an RGS protein by MAP kinase in yeast. J Biol Chem 274(51):36387-91 SGD PMID 10593933
  5. Matheos D, et al. (2004) Pheromone-induced polarization is dependent on the Fus3p MAPK acting through the formin Bni1p. J Cell Biol 165(1):99-109 SGD PMID 15067022
  6. Ptashne M and Gann A (2003) Signal transduction. Imposing specificity on kinases. Science 299(5609):1025-7 SGD PMID 12586931

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