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Systematic name YAL048C
Gene name GEM1
Aliases GON1
Feature type ORF, Verified
Coordinates Chr I:54789..52801
Primary SGDID S000000046

Description of YAL048C: Outer mitochondrial membrane GTPase, subunit of the ERMES complex; potential regulatory subunit of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; ortholog of metazoan Miro GTPases[1][2][3][4]


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  1. Frederick RL, et al. (2004) Yeast Miro GTPase, Gem1p, regulates mitochondrial morphology via a novel pathway. J Cell Biol 167(1):87-98 SGD PMID 15479738
  2. Kornmann B, et al. (2011) The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections. Proc Natl Acad Sci U S A 108(34):14151-6 SGD PMID 21825164
  3. Stroud DA, et al. (2011) Composition and Topology of the Endoplasmic Reticulum-Mitochondria Encounter Structure. J Mol Biol () SGD PMID 21945531
  4. Wolff AM, et al. (1999) The open reading frame YAL048c affects the secretion of proteinase A in S. cerevisiae. Yeast 15(5):427-34 SGD PMID 10220001

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