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Systematic name YAL035W
Gene name FUN12
Aliases yIF2
Feature type ORF, Verified
Coordinates Chr I:76427..79435
Primary SGDID S000000033

Description of YAL035W: GTPase required for general translation initiation; promotes Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; protein abundance increases in response to DNA replication stress; homolog of bacterial IF2[1][2][3]


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  1. Choi SK, et al. (1998) Promotion of met-tRNAiMet binding to ribosomes by yIF2, a bacterial IF2 homolog in yeast. Science 280(5370):1757-60 SGD PMID 9624054
  2. Lee JH, et al. (2002) Initiation factor eIF5B catalyzes second GTP-dependent step in eukaryotic translation initiation. Proc Natl Acad Sci U S A 99(26):16689-94 SGD PMID 12471154
  3. Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.LID - 10.1038/ncb2549 [doi] Nat Cell Biol () SGD PMID 22842922

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