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Systematic name YAL028W
Gene name FRT2
Aliases HPH2
Feature type ORF, Verified
Coordinates Chr I:92900..94486
Primary SGDID S000000026

Description of YAL028W: Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication[1][2][3][4][5]


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Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [5] [6]



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  1. Burri L and Lithgow T (2004) A complete set of SNAREs in yeast. Traffic 5(1):45-52 SGD PMID 14675424
  2. Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61 SGD PMID 16169922
  3. Heath VL, et al. (2004) Hph1p and Hph2p, novel components of calcineurin-mediated stress responses in Saccharomyces cerevisiae. Eukaryot Cell 3(3):695-704 SGD PMID 15189990
  4. Pina FJ, et al. (2011) Hph1 and hph2 are novel components of the sec63/sec62 posttranslational translocation complex that aid in vacuolar proton ATPase biogenesis. Eukaryot Cell 10(1):63-71 SGD PMID 21097665
  5. 5.0 5.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415 Cite error: Invalid <ref> tag; name "S000074306" defined multiple times with different content
  6. submitted by Jeff Ubersax on 2004-01-21

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