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Systematic name YAL012W
Gene name CYS3
Aliases CYI1, FUN35, STR1
Feature type ORF, Verified
Coordinates Chr I:130799..131983
Primary SGDID S000000010

Description of YAL012W: Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine; protein abundance increases in response to DNA replication stress[1][2][3][4]


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DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in sulfur limited chemostat cultures versus sulfur excess. [5] [6]



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  1. Cherest H, et al. (1993) Cysteine biosynthesis in Saccharomyces cerevisiae occurs through the transsulfuration pathway which has been built up by enzyme recruitment. J Bacteriol 175(17):5366-74 SGD PMID 8366024
  2. Ono B, et al. (1991) Regulation of cystathionine gamma-lyase in Saccharomyces cerevisiae. Yeast 7(8):843-8 SGD PMID 1789005
  3. Ono B, et al. (1992) Cloning and characterization of the CYS3 (CYI1) gene of Saccharomyces cerevisiae. J Bacteriol 174(10):3339-47 SGD PMID 1577698
  4. Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.LID - 10.1038/ncb2549 [doi] Nat Cell Biol () SGD PMID 22842922
  5. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  6. submitted by Viktor Boer on 2003-07-25

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