YJR024C

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Systematic name YJR024C
Gene name MDE1
Aliases
Feature type ORF, Verified
Coordinates Chr X:470964..470230
Primary SGDID S000003785


Description of YJR024C: 5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant[1][2][3][4][5]




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References

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  1. Lesage G, et al. (2004) Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin. Genetics 167(1):35-49 SGD PMID 15166135
  2. Panse VG, et al. (2004) A proteome-wide approach identifies sumoylated substrate proteins in yeast. J Biol Chem 279(40):41346-51 SGD PMID 15292183
  3. Pirkov I, et al. (2008) A complete inventory of all enzymes in the eukaryotic methionine salvage pathway. FEBS J 275(16):4111-20 SGD PMID 18625006
  4. Reinoso-Martin C, et al. (2003) The yeast protein kinase C cell integrity pathway mediates tolerance to the antifungal drug caspofungin through activation of Slt2p mitogen-activated protein kinase signaling. Eukaryot Cell 2(6):1200-10 SGD PMID 14665455
  5. Sekowska A, et al. (2004) Bacterial variations on the methionine salvage pathway. BMC Microbiol 4():9 SGD PMID 15102328

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