YGR133W
Share your knowledge...Edit this entry! <protect>
| Systematic name | YGR133W |
| Gene name | PEX4 |
| Aliases | PAS2, UBC10 |
| Feature type | ORF, Verified |
| Coordinates | Chr VII:756896..757447 |
| Primary SGDID | S000003365 |
Description of YGR133W: Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis[1][2][3][4]
</protect>
Community Commentary
About Community Commentary. Please share your knowledge!
Protein Details
Other Protein Details
Other Topic: Homology
Homology was found, at the sequence and domain-composition level, between several components of the Peroxisomal protein import machinery and components of the Endoplasmic Reticulum Associated Decay (ERAD) pathway. This suggests a common evolutionary origin for both systems and a similar mechanism of action. The homology relationships can be stablished between Pex1,Pex6 and cdc48; Pex2 and Hrd1; Pex4 and Ubc1; and Pex5 and Hrd3. [5] [6]
<protect>
References
See Help:References on how to add references
- ↑ Eckert JH and Johnsson N (2003) Pex10p links the ubiquitin conjugating enzyme Pex4p to the protein import machinery of the peroxisome. J Cell Sci 116(Pt 17):3623-34 SGD PMID 12876220
- ↑ Erdmann R, et al. (1989) Isolation of peroxisome-deficient mutants of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 86(14):5419-23 SGD PMID 2568633
- ↑ Kragt A, et al. (2005) The Saccharomyces cerevisiae peroxisomal import receptor Pex5p is monoubiquitinated in wild type cells. J Biol Chem 280(9):7867-74 SGD PMID 15632140
- ↑ Wiebel FF and Kunau WH (1992) The Pas2 protein essential for peroxisome biogenesis is related to ubiquitin-conjugating enzymes. Nature 359(6390):73-6 SGD PMID 1326082
- ↑ Gabaldon T, et al. (2006) Origin and evolution of the peroxisomal proteome. Biol Direct 1():8 SGD PMID 16556314
- ↑ submitted by Toni Gabaldon on 2006-04-12
See Help:Categories on how to add the wiki page for this gene to a Category </protect>
