YGR116W

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Systematic name YGR116W
Gene name SPT6
Aliases CRE2, SSN20
Feature type ORF, Verified
Coordinates Chr VII:720409..724764
Primary SGDID S000003348


Description of YGR116W: Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region[1][2][3][4]




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References

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  1. Bortvin A and Winston F (1996) Evidence that Spt6p controls chromatin structure by a direct interaction with histones. Science 272(5267):1473-6 SGD PMID 8633238
  2. Close D, et al. (2011) Crystal Structures of the S. cerevisiae Spt6 Core and C-Terminal Tandem SH2 Domain. J Mol Biol 408(4):697-713 SGD PMID 21419780
  3. Hartzog GA, et al. (1998) Evidence that Spt4, Spt5, and Spt6 control transcription elongation by RNA polymerase II in Saccharomyces cerevisiae. Genes Dev 12(3):357-69 SGD PMID 9450930
  4. Kaplan CD, et al. (2003) Transcription elongation factors repress transcription initiation from cryptic sites. Science 301(5636):1096-9 SGD PMID 12934008

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