YHR149C
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| Systematic name | YHR149C |
| Gene name | SKG6 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr VIII:396659..394455 |
| Primary SGDID | S000001192 |
Description of YHR149C: Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p[1][2][3][4]
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Contents
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [4] [5]
Transmembrane Domain GxxxG-like motif
The transmembrane domain of this protein contains GvavAvpvG. The presence of multiple, chained GxxxG-like motifs [6] strongly indicates that Skg6p dimerises.
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References
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- ↑ Drees BL, et al. (2001) A protein interaction map for cell polarity development. J Cell Biol 154(3):549-71 SGD PMID 11489916
- ↑ Tomishige N, et al. (2005) SKG1, a suppressor gene of synthetic lethality of kex2Deltagas1Delta mutations, encodes a novel membrane protein that affects cell wall composition. Yeast 22(2):141-55 SGD PMID 15645486
- ↑ Tomishige N, et al. (2005) SKG6, a suppressor gene of synthetic lethality of kex2Delta gas1Delta mutations, encodes a novel membrane protein showing polarized intracellular localization. J Gen Appl Microbiol 51(5):323-6 SGD PMID 16314687
- ↑ 4.0 4.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64
SGD PMID 14574415 Cite error: Invalid
<ref>tag; name "S000074306" defined multiple times with different content - ↑ submitted by Jeff Ubersax on 2004-01-27
- ↑ Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242
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