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Systematic name RDN5-1
Gene name RDN5-1
Aliases RDN5
Feature type rRNA
Coordinates Chr XII:459676..459796
Primary SGDID S000006479

Description of RDN5-1: 5S ribosomal RNA (5S rRNA); only complete sequence of 6 repeated RDN5 alleles; able to support viability when provided as sole form of 5S rRNA; component of the large (60S) ribosomal subunit; localized to the nucleolus via interaction with Rpl5p; may play a role in translational frame fidelity; transcription is mediated by PolIII and activated by TFIIIA and TFIIIE[1][2][3][4][5]


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  1. Camier S, et al. (1995) The only essential function of TFIIIA in yeast is the transcription of 5S rRNA genes. Proc Natl Acad Sci U S A 92(20):9338-42 SGD PMID 7568129
  2. Dieci G, et al. (2009) Positive modulation of RNA polymerase III transcription by ribosomal proteins. Biochem Biophys Res Commun 379(2):489-93 SGD PMID 19116144
  3. Dinman JD and Wickner RB (1995) 5 S rRNA is involved in fidelity of translational reading frame. Genetics 141(1):95-105 SGD PMID 8536994
  4. Kiparisov S, et al. (2005) Structural and functional analysis of 5S rRNA in Saccharomyces cerevisiae. Mol Genet Genomics 274(3):235-47 SGD PMID 16047201
  5. Michael WM and Dreyfuss G (1996) Distinct domains in ribosomal protein L5 mediate 5 S rRNA binding and nucleolar localization. J Biol Chem 271(19):11571-4 SGD PMID 8626719

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