YGR023W
(Redirected from MTL1)
Share your knowledge...Edit this entry! <protect>
Systematic name | YGR023W |
Gene name | MTL1 |
Aliases | |
Feature type | ORF, Verified |
Coordinates | Chr VII:529264..530919 |
Primary SGDID | S000003255 |
Description of YGR023W: Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p[1][2][3]
</protect>
Community Commentary
About Community Commentary. Please share your knowledge!
Transmembrane Domain GxxxG
The transmembrane domain of Mtl1p shows homology with the SKG6/AXL2 alpha-helix transmembrane domain (IPR014805). In particular, this domain begins with iiiGcvvG. The presence of a GxxxG motif [4] strongly indicates that Mtl1p dimerises.
<protect>
References
See Help:References on how to add references
- ↑ Ketela T, et al. (1999) Saccharomyces cerevisiae mid2p is a potential cell wall stress sensor and upstream activator of the PKC1-MPK1 cell integrity pathway. J Bacteriol 181(11):3330-40 SGD PMID 10348843
- ↑ Rajavel M, et al. (1999) Mid2 is a putative sensor for cell integrity signaling in Saccharomyces cerevisiae. Mol Cell Biol 19(6):3969-76 SGD PMID 10330137
- ↑ Vilella F, et al. (2005) Pkc1 and the upstream elements of the cell integrity pathway in Saccharomyces cerevisiae, Rom2 and Mtl1, are required for cellular responses to oxidative stress. J Biol Chem 280(10):9149-59 SGD PMID 15637049
- ↑ Senes A, Engel DE and DeGrado WF (2004) Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs. Curr Opin Struct Biol. 2004 14(4):465-79. PMID 15313242
See Help:Categories on how to add the wiki page for this gene to a Category </protect>