YNL015W

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Systematic name YNL015W
Gene name PBI2
Aliases I2B, IB2, LMA1
Feature type ORF, Verified
Coordinates Chr XIV:605384..605611
Primary SGDID S000004960


Description of YNL015W: Cytosolic inhibitor of vacuolar proteinase B (PRB1), required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion[1][2][3][4]




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References

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  1. Betz H (1975) Levels and turnover of the proteinase B inhibitors in yeast. Biochim Biophys Acta 404(1):142-51 SGD PMID 1100120
  2. Elazar Z, et al. (2003) Involvement of LMA1 and GATE-16 family members in intracellular membrane dynamics. Biochim Biophys Acta 1641(2-3):145-56 SGD PMID 12914955
  3. Slusarewicz P, et al. (1997) I2B is a small cytosolic protein that participates in vacuole fusion. Proc Natl Acad Sci U S A 94(11):5582-7 SGD PMID 9159115
  4. Xu Z, et al. (1997) A heterodimer of thioredoxin and I(B)2 cooperates with Sec18p (NSF) to promote yeast vacuole inheritance. J Cell Biol 136(2):299-306 SGD PMID 9015301

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