YLR299W

From SGD-Wiki
(Redirected from CIS2)
Jump to: navigation, search

Share your knowledge...Edit this entry! <protect>

Systematic name YLR299W
Gene name ECM38
Aliases CIS2
Feature type ORF, Verified
Coordinates Chr XII:726069..728051
Primary SGDID S000004290


Description of YLR299W: Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation[1][2][3][4]




</protect>

Community Commentary

About Community Commentary. Please share your knowledge!

DNA and RNA Details

Other DNA and RNA Details

Other Topic: expression

Specifically higher expression in nitrogen limited chemostat cultures versus nitrogen excess. [5] [6]





<protect>

References

See Help:References on how to add references

  1. Kumar C, et al. (2003) Investigations into the polymorphisms at the ECM38 locus of two widely used Saccharomyces cerevisiae S288C strains, YPH499 and BY4742. Yeast 20(10):857-63 SGD PMID 12868055
  2. Kumar C, et al. (2003) Utilization of glutathione as an exogenous sulfur source is independent of gamma-glutamyl transpeptidase in the yeast Saccharomyces cerevisiae: evidence for an alternative gluathione degradation pathway. FEMS Microbiol Lett 219(2):187-94 SGD PMID 12620619
  3. Springael JY and Penninckx MJ (2003) Nitrogen-source regulation of yeast gamma-glutamyl transpeptidase synthesis involves the regulatory network including the GATA zinc-finger factors Gln3, Nil1/Gat1 and Gzf3. Biochem J 371(Pt 2):589-95 SGD PMID 12529169
  4. Ubiyvovk VM, et al. (2006) Role of gamma-glutamyltranspeptidase in detoxification of xenobiotics in the yeasts Hansenula polymorpha and Saccharomyces cerevisiae. Cell Biol Int 30(8):665-71 SGD PMID 16857395
  5. Boer VM, et al. (2003) The genome-wide transcriptional responses of Saccharomyces cerevisiae grown on glucose in aerobic chemostat cultures limited for carbon, nitrogen, phosphorus, or sulfur. J Biol Chem 278(5):3265-74 SGD PMID 12414795
  6. submitted by Viktor Boer on 2003-07-25

See Help:Categories on how to add the wiki page for this gene to a Category </protect>