YPL120W
(Redirected from APG6)
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| Systematic name | YPL120W |
| Gene name | VPS30 |
| Aliases | APG6, ATG6, VPT30 |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:322071..323744 |
| Primary SGDID | S000006041 |
Description of YPL120W: Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1[1][2][3][4]
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References
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- ↑ Furuya N, et al. (2005) The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 1(1):46-52 SGD PMID 16874027
- ↑ Kihara A, et al. (2001) Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol 152(3):519-30 SGD PMID 11157979
- ↑ Seaman MN, et al. (1997) Endosome to Golgi retrieval of the vacuolar protein sorting receptor, Vps10p, requires the function of the VPS29, VPS30, and VPS35 gene products. J Cell Biol 137(1):79-92 SGD PMID 9105038
- ↑ Tsukada M and Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74 SGD PMID 8224160
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