Difference between revisions of "YPR200C"
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| + | === Other === | ||
| + | [[Category:Topic:Other]] | ||
| + | ==== Other ==== | ||
| + | [[Category:Topic:Other:Other]] | ||
| + | Acr2p is an arsenate reductase that is related to protein phosphotyrosine phosphateses. The active site of Acr2p has the consensus phosphatese HC(X)5R motif. <ref name='S000065875'>Mukhopadhyay R and Rosen BP (2001) The phosphatase C(X)5R motif is required for catalytic activity of the Saccharomyces cerevisiae Acr2p arsenate reductase. J Biol Chem 276(37):34738-42 {{SGDpaper|S000065875}} PMID 11461905</ref> <ref name = 'CAset9517-2003-07-31'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9517 Barry Rosen] on 2003-07-31</ref> | ||
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| + | {{ShortCenteredHR}} | ||
| + | |||
| + | Purified Acr2p reduces arsenate to arsenite using glutaredoxin and GSH as reductants. <ref name='S000054698'>Mukhopadhyay R, et al. (2000) Purification and characterization of ACR2p, the Saccharomyces cerevisiae arsenate reductase. J Biol Chem 275(28):21149-57 {{SGDpaper|S000054698}} PMID 10801893</ref> <ref name = 'CAset9517-2003-07-31'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9517 Barry Rosen] on 2003-07-31</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | === Protein Details === | ||
| + | [[Category:Topic:Protein Details]] | ||
| + | ==== Protein Function/Process ==== | ||
| + | [[Category:Topic:Protein Details:Protein Function/Process]] | ||
| + | |||
| + | Disruption of ACR2 resulted in senstivity to arsenate but not arsenite. Purified Acr2p was shown to have arsenate reductase activity. <ref name='S000058383'>Mukhopadhyay R and Rosen BP (1998) Saccharomyces cerevisiae ACR2 gene encodes an arsenate reductase. FEMS Microbiol Lett 168(1):127-36 {{SGDpaper|S000058383}} PMID 9812373</ref> <ref name = 'CAset9517-2003-07-31'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9517 Barry Rosen] on 2003-07-31</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | |||
| + | Acr2p, which is related to protein phosphotyrosine phosphatases, has arsenate reductase activity but not protein phosphotyrosine phosphatase activity. Three mutations were sufficient to change the activity from a reductase to a phosphatase. <ref name='S000073629'>Mukhopadhyay R, et al. (2003) Directed evolution of a yeast arsenate reductase into a protein-tyrosine phosphatase. J Biol Chem 278(27):24476-80 {{SGDpaper|S000073629}} PMID 12711608</ref> <ref name = 'CAset9517-2003-07-31'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9517 Barry Rosen] on 2003-07-31</ref> | ||
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| + | {{ShortCenteredHR}} | ||
__TOC__ | __TOC__ | ||
==Community Commentary== | ==Community Commentary== | ||
{{CommentaryHelp}} | {{CommentaryHelp}} | ||
| + | === Other === | ||
| + | [[Category:Topic:Other]] | ||
| + | ==== Other ==== | ||
| + | [[Category:Topic:Other:Other]] | ||
| + | |||
| + | Acr2p is an arsenate reductase that is related to protein phosphotyrosine phosphateses. The active site of Acr2p has the consensus phosphatese HC(X)5R motif. <ref name='S000065875'>Mukhopadhyay R and Rosen BP (2001) The phosphatase C(X)5R motif is required for catalytic activity of the Saccharomyces cerevisiae Acr2p arsenate reductase. J Biol Chem 276(37):34738-42 {{SGDpaper|S000065875}} PMID 11461905</ref> <ref name = 'CAset9517-2003-07-31'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9517 Barry Rosen] on 2003-07-31</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | |||
| + | Purified Acr2p reduces arsenate to arsenite using glutaredoxin and GSH as reductants. <ref name='S000054698'>Mukhopadhyay R, et al. (2000) Purification and characterization of ACR2p, the Saccharomyces cerevisiae arsenate reductase. J Biol Chem 275(28):21149-57 {{SGDpaper|S000054698}} PMID 10801893</ref> <ref name = 'CAset9517-2003-07-31'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9517 Barry Rosen] on 2003-07-31</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | === Protein Details === | ||
| + | [[Category:Topic:Protein Details]] | ||
| + | ==== Protein Function/Process ==== | ||
| + | [[Category:Topic:Protein Details:Protein Function/Process]] | ||
| + | |||
| + | Disruption of ACR2 resulted in senstivity to arsenate but not arsenite. Purified Acr2p was shown to have arsenate reductase activity. <ref name='S000058383'>Mukhopadhyay R and Rosen BP (1998) Saccharomyces cerevisiae ACR2 gene encodes an arsenate reductase. FEMS Microbiol Lett 168(1):127-36 {{SGDpaper|S000058383}} PMID 9812373</ref> <ref name = 'CAset9517-2003-07-31'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9517 Barry Rosen] on 2003-07-31</ref> | ||
| + | |||
| + | {{ShortCenteredHR}} | ||
| + | |||
| + | Acr2p, which is related to protein phosphotyrosine phosphatases, has arsenate reductase activity but not protein phosphotyrosine phosphatase activity. Three mutations were sufficient to change the activity from a reductase to a phosphatase. <ref name='S000073629'>Mukhopadhyay R, et al. (2003) Directed evolution of a yeast arsenate reductase into a protein-tyrosine phosphatase. J Biol Chem 278(27):24476-80 {{SGDpaper|S000073629}} PMID 12711608</ref> <ref name = 'CAset9517-2003-07-31'>submitted by [http://db.yeastgenome.org/cgi-bin/colleague/colleagueSearch?id=9517 Barry Rosen] on 2003-07-31</ref> | ||
| + | {{ShortCenteredHR}} | ||
==References== | ==References== | ||
<!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | <!-- REFERENCES ARE AUTOMATICALLY GENERATED. PLEASE DON'T EDIT THIS SECTION--> | ||
{{RefHelp}} | {{RefHelp}} | ||
Revision as of 17:05, 23 January 2007
Share your knowledge...Edit this entry!
| Systematic name | YPR200C | |
| Gene name | ARR2 | |
| Aliases | ACR2 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr XVI:939667..939275 | |
| Don't edit this box! It's automatically regenerated, and edits will be lost when the update script runs. | ||
Description of YPR200C: Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p[1][2]
Other
Other
Acr2p is an arsenate reductase that is related to protein phosphotyrosine phosphateses. The active site of Acr2p has the consensus phosphatese HC(X)5R motif. [3] [4]
Purified Acr2p reduces arsenate to arsenite using glutaredoxin and GSH as reductants. [2] [4]
Protein Details
Protein Function/Process
Disruption of ACR2 resulted in senstivity to arsenate but not arsenite. Purified Acr2p was shown to have arsenate reductase activity. [1] [4]
Acr2p, which is related to protein phosphotyrosine phosphatases, has arsenate reductase activity but not protein phosphotyrosine phosphatase activity. Three mutations were sufficient to change the activity from a reductase to a phosphatase. [5] [4]
Contents
Community Commentary
About Community Commentary. Please share your knowledge!
Other
Other
Acr2p is an arsenate reductase that is related to protein phosphotyrosine phosphateses. The active site of Acr2p has the consensus phosphatese HC(X)5R motif. [3] [4]
Purified Acr2p reduces arsenate to arsenite using glutaredoxin and GSH as reductants. [2] [4]
Protein Details
Protein Function/Process
Disruption of ACR2 resulted in senstivity to arsenate but not arsenite. Purified Acr2p was shown to have arsenate reductase activity. [1] [4]
Acr2p, which is related to protein phosphotyrosine phosphatases, has arsenate reductase activity but not protein phosphotyrosine phosphatase activity. Three mutations were sufficient to change the activity from a reductase to a phosphatase. [5] [4]
References
See Help:References on how to add references
- ↑ 1.0 1.1 1.2 Mukhopadhyay R and Rosen BP (1998) Saccharomyces cerevisiae ACR2 gene encodes an arsenate reductase. FEMS Microbiol Lett 168(1):127-36 SGD PMID 9812373
- ↑ 2.0 2.1 2.2 Mukhopadhyay R, et al. (2000) Purification and characterization of ACR2p, the Saccharomyces cerevisiae arsenate reductase. J Biol Chem 275(28):21149-57
SGD PMID 10801893 Cite error: Invalid
<ref>tag; name "S000054698" defined multiple times with different content Cite error: Invalid<ref>tag; name "S000054698" defined multiple times with different content - ↑ 3.0 3.1 Mukhopadhyay R and Rosen BP (2001) The phosphatase C(X)5R motif is required for catalytic activity of the Saccharomyces cerevisiae Acr2p arsenate reductase. J Biol Chem 276(37):34738-42 SGD PMID 11461905
- ↑ 4.0 4.1 4.2 4.3 4.4 4.5 4.6 4.7 submitted by Barry Rosen on 2003-07-31
- ↑ 5.0 5.1 Mukhopadhyay R, et al. (2003) Directed evolution of a yeast arsenate reductase into a protein-tyrosine phosphatase. J Biol Chem 278(27):24476-80 SGD PMID 12711608
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