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Systematic name YPR173C
Gene name VPS4
Aliases CSC1, DID6, END13, GRD13, VPL4, VPT10
Feature type ORF, Verified
Coordinates Chr XVI:887837..886524
Primary SGDID S000006377

Description of YPR173C: AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism[1][2][3][4][5][6]


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  1. Azmi I, et al. (2006) Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1. J Cell Biol 172(5):705-17 SGD PMID 16505166
  2. Babst M, et al. (1998) The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J 17(11):2982-93 SGD PMID 9606181
  3. Babst M, et al. (2002) Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev Cell 3(2):271-82 SGD PMID 12194857
  4. Kumar A, et al. (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19 SGD PMID 11914276
  5. Lottridge JM, et al. (2006) Vta1p and Vps46p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body. Proc Natl Acad Sci U S A 103(16):6202-7 SGD PMID 16601096
  6. Wang P, et al. (2005) AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism. EMBO J 24(17):2989-99 SGD PMID 16096648

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