Difference between revisions of "YPR173C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006377 YPR173C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006377 YPR173C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''VPS4 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''VPS4 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
|nowrap| Chr XVI:887833..886520
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|nowrap| Chr XVI:887837..886524
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000006377
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000006377
 
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'''Description of YPR173C:''' AAA-type ATPase required for efficient late endosome to vacuole transport; catalyzes the release of an endosomal membrane-associated class E VPS protein complex; regulates cellular sterol metabolism; cytoplasmic and endosomal localization<ref name='S000086181'>Wang P, et al. (2005) AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism. EMBO J 24(17):2989-99 {{SGDpaper|S000086181}} PMID 16096648</ref><ref name='S000069459'>Kumar A, et al. (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19 {{SGDpaper|S000069459}} PMID 11914276</ref><ref name='S000044124'>Babst M, et al. (1998) The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J 17(11):2982-93
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'''Description of YPR173C:''' AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism<ref name='S000120430'>Azmi I, et al. (2006) Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1. J Cell Biol 172(5):705-17 {{SGDpaper|S000120430}} PMID 16505166</ref><ref name='S000044124'>Babst M, et al. (1998) The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J 17(11):2982-93 {{SGDpaper|S000044124}} PMID 9606181</ref><ref name='S000071351'>Babst M, et al. (2002) Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev Cell 3(2):271-82 {{SGDpaper|S000071351}} PMID 12194857</ref><ref name='S000069459'>Kumar A, et al. (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19 {{SGDpaper|S000069459}} PMID 11914276</ref><ref name='S000114798'>Lottridge JM, et al. (2006) Vta1p and Vps46p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body. Proc Natl Acad Sci U S A 103(16):6202-7 {{SGDpaper|S000114798}} PMID 16601096</ref><ref name='S000086181'>Wang P, et al. (2005) AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism. EMBO J 24(17):2989-99
  {{SGDpaper|S000044124}} PMID 9606181</ref>
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  {{SGDpaper|S000086181}} PMID 16096648</ref>
 
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Latest revision as of 07:45, 23 January 2012

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Systematic name YPR173C
Gene name VPS4
Aliases CSC1, DID6, END13, GRD13, VPL4, VPT10
Feature type ORF, Verified
Coordinates Chr XVI:887837..886524
Primary SGDID S000006377


Description of YPR173C: AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism[1][2][3][4][5][6]




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References

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  1. Azmi I, et al. (2006) Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1. J Cell Biol 172(5):705-17 SGD PMID 16505166
  2. Babst M, et al. (1998) The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J 17(11):2982-93 SGD PMID 9606181
  3. Babst M, et al. (2002) Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev Cell 3(2):271-82 SGD PMID 12194857
  4. Kumar A, et al. (2002) Subcellular localization of the yeast proteome. Genes Dev 16(6):707-19 SGD PMID 11914276
  5. Lottridge JM, et al. (2006) Vta1p and Vps46p regulate the membrane association and ATPase activity of Vps4p at the yeast multivesicular body. Proc Natl Acad Sci U S A 103(16):6202-7 SGD PMID 16601096
  6. Wang P, et al. (2005) AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism. EMBO J 24(17):2989-99 SGD PMID 16096648

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