Difference between revisions of "YPL267W"
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| − | '''Description of YPL267W:''' Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein<ref name=' | + | '''Description of YPL267W:''' Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein<ref name='S000074306'>Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 {{SGDpaper|S000074306}} PMID 14574415</ref><ref name='S000119207'>Martinez JS, et al. (2006) Acm1 is a negative regulator of the CDH1-dependent anaphase-promoting complex/cyclosome in budding yeast. Mol Cell Biol 26(24):9162-76 {{SGDpaper|S000119207}} PMID 17030612</ref><ref name='S000126489'>Enquist-Newman M, et al. (2008) Modulation of the Mitotic Regulatory Network by APC-Dependent Destruction of the Cdh1 Inhibitor Acm1. Mol Cell 30(4):437-46 {{SGDpaper|S000126489}} PMID 18498748</ref><ref name='S000126632'>Ostapenko D, et al. (2008) Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation. Mol Cell Biol 28(15):4653-64 |
| − | {{SGDpaper| | + | {{SGDpaper|S000126632}} PMID 18519589</ref> |
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Revision as of 14:05, 31 March 2009
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| Systematic name | YPL267W |
| Gene name | ACM1 |
| Aliases | |
| Feature type | ORF, Verified |
| Coordinates | Chr XVI:38169..38798 |
| Primary SGDID | S000006188 |
Description of YPL267W: Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein[1][2][3][4]
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Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [1] [5]
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References
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- ↑ 1.0 1.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ Martinez JS, et al. (2006) Acm1 is a negative regulator of the CDH1-dependent anaphase-promoting complex/cyclosome in budding yeast. Mol Cell Biol 26(24):9162-76 SGD PMID 17030612
- ↑ Enquist-Newman M, et al. (2008) Modulation of the Mitotic Regulatory Network by APC-Dependent Destruction of the Cdh1 Inhibitor Acm1. Mol Cell 30(4):437-46 SGD PMID 18498748
- ↑ Ostapenko D, et al. (2008) Pseudosubstrate inhibition of the anaphase-promoting complex by Acm1: regulation by proteolysis and Cdc28 phosphorylation. Mol Cell Biol 28(15):4653-64 SGD PMID 18519589
- ↑ submitted by Jeff Ubersax on 2004-01-29
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