YPL209C
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| Systematic name | YPL209C | |
| Gene name | IPL1 | |
| Aliases | PAC15 | |
| Feature type | ORF, Verified | |
| Coordinates | Chr XVI:157592..156489 | |
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Description of YPL209C: Aurora kinase involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; associates with Sli15p, which promotes Ipl1p association with mitotic spindle[1][2][3]
Alleles, Strains, and Phenotypes
Point Mutation
Allele: ipl1-321
Strain Background: W303
Phenotype(s): Temperature(Heat) Sensitive
Impairing Ipl1p function restores chromosome attachment in the mtw1-1 mutant , suggesting that Ipl1p promotes the turnover of improper kinetochore-microtubule interactions. [4] [5]
Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [6] [7]
Contents
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Alleles, Strains, and Phenotypes
Point Mutation
Allele: ipl1-321
Strain Background: W303
Phenotype(s): Temperature(Heat) Sensitive
Impairing Ipl1p function restores chromosome attachment in the mtw1-1 mutant , suggesting that Ipl1p promotes the turnover of improper kinetochore-microtubule interactions. [4] [5]
Protein Details
Protein Modification
Modification(s): Phosphorylation
Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [6] [7]
References
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- ↑ Vas AC, et al. (2006) In Vivo Analysis of Chromosome Condensation in Saccharomyces cerevisiae. Mol Biol Cell () SGD PMID 17151360
- ↑ Cheeseman IM, et al. (2002) Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111(2):163-72 SGD PMID 12408861
- ↑ Kang J, et al. (2001) Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. J Cell Biol 155(5):763-74 SGD PMID 11724818
- ↑ 4.0 4.1 Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
- ↑ 5.0 5.1 submitted by Benjamin Pinsky on 2004-03-04
- ↑ 6.0 6.1 Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
- ↑ 7.0 7.1 submitted by Jeff Ubersax on 2004-01-29
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