Difference between revisions of "YPL209C"

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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://db.yeastgenome.org/cgi-bin/locus.pl?locus=YPL209C YPL209C]  
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Systematic name''' || [http://www.yeastgenome.org/cgi-bin/locus.pl?dbid=S000006130 YPL209C]  
 
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''IPL1 ''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Gene name'''        ||''IPL1 ''
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
 
|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Coordinates'''
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|nowrap| Chr XVI:157592..156489
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|nowrap| Chr XVI:157593..156490
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|valign="top" nowrap bgcolor="{{SGDblue}}"| '''Primary SGDID'''          || S000006130
 
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'''Description of {{PAGENAME}}:''' Aurora kinase involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; associates with Sli15p, which promotes Ipl1p association with mitotic spindle<ref name='S000119930'>Vas AC, et al. (2007) In Vivo Analysis of Chromosome Condensation in Saccharomyces cerevisiae. Mol Biol Cell 18(2):557-68 {{SGDpaper|S000119930}} PMID 17151360</ref><ref name='S000071581'>Cheeseman IM, et al. (2002) Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111(2):163-72 {{SGDpaper|S000071581}} PMID 12408861</ref><ref name='S000066223'>Kang J, et al. (2001) Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. J Cell Biol 155(5):763-74
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'''Description of YPL209C:''' Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation<ref name='S000071581'>Cheeseman IM, et al. (2002) Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111(2):163-72 {{SGDpaper|S000071581}} PMID 12408861</ref><ref name='S000066223'>Kang Js JS, et al. (2001) Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. J Cell Biol 155(5):763-74 {{SGDpaper|S000066223}} PMID 11724818</ref><ref name='S000129008'>Nakajima Y, et al. (2009) Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1772-84 {{SGDpaper|S000129008}} PMID 19158380</ref><ref name='S000146599'>Shirk K, et al. (2011) The Aurora kinase Ipl1 is necessary for spindle pole body cohesion during budding yeast meiosis. J Cell Sci 124(Pt 17):2891-6 {{SGDpaper|S000146599}} PMID 21878496</ref><ref name='S000119930'>Vas AC, et al. (2007) In vivo analysis of chromosome condensation in Saccharomyces cerevisiae. Mol Biol Cell 18(2):557-68
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  {{SGDpaper|S000066223}} PMID 11724818</ref>
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  {{SGDpaper|S000119930}} PMID 17151360</ref>
 
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'''Allele''': ipl1-321<br>
 
'''Allele''': ipl1-321<br>
  
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'''Strain Background''': W303<br>
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'''Strain Background''': W303 (''see [[CommunityW303.html|detailed notes]] from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study'')
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'''Phenotype(s)''': Temperature(Heat) Sensitive [[Category:Phenotype:Temperature(Heat) Sensitive]]
 
'''Phenotype(s)''': Temperature(Heat) Sensitive [[Category:Phenotype:Temperature(Heat) Sensitive]]
  
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==References==
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==References==
 
==References==

Latest revision as of 14:05, 20 July 2012

Share your knowledge...Edit this entry! <protect>

Systematic name YPL209C
Gene name IPL1
Aliases PAC15
Feature type ORF, Verified
Coordinates Chr XVI:157593..156490
Primary SGDID S000006130


Description of YPL209C: Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for SPB cohesion and prevention of multipolar spindle formation[1][2][3][4][5]




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Community Commentary

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Alleles, Strains, and Phenotypes

Point Mutation

Allele: ipl1-321

Strain Background: W303 (see detailed notes from Rodney Rothstein and Stephan Bartsch for the W303 strain used in the study)
Phenotype(s): Temperature(Heat) Sensitive

Impairing Ipl1p function restores chromosome attachment in the mtw1-1 mutant , suggesting that Ipl1p promotes the turnover of improper kinetochore-microtubule interactions. [6] [7]

Protein Details

Protein Modification

Modification(s): Phosphorylation

Identified as an efficient substrate of Clb2-Cdk1-as1 in a screen of a proteomic GST-fusion library. [8] [9]




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References

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  1. ↑ Cheeseman IM, et al. (2002) Phospho-regulation of kinetochore-microtubule attachments by the Aurora kinase Ipl1p. Cell 111(2):163-72 SGD PMID 12408861
  2. ↑ Kang Js JS, et al. (2001) Functional cooperation of Dam1, Ipl1, and the inner centromere protein (INCENP)-related protein Sli15 during chromosome segregation. J Cell Biol 155(5):763-74 SGD PMID 11724818
  3. ↑ Nakajima Y, et al. (2009) Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae. Mol Biol Cell 20(6):1772-84 SGD PMID 19158380
  4. ↑ Shirk K, et al. (2011) The Aurora kinase Ipl1 is necessary for spindle pole body cohesion during budding yeast meiosis. J Cell Sci 124(Pt 17):2891-6 SGD PMID 21878496
  5. ↑ Vas AC, et al. (2007) In vivo analysis of chromosome condensation in Saccharomyces cerevisiae. Mol Biol Cell 18(2):557-68 SGD PMID 17151360
  6. ↑ Pinsky BA, et al. (2003) An Mtw1 complex promotes kinetochore biorientation that is monitored by the Ipl1/Aurora protein kinase. Dev Cell 5(5):735-45 SGD PMID 14602074
  7. ↑ submitted by Benjamin Pinsky on 2004-03-04
  8. ↑ Ubersax JA, et al. (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64 SGD PMID 14574415
  9. ↑ submitted by Jeff Ubersax on 2004-01-29

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References

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See Help:Categories on how to add the wiki page for this gene to a Category </protect>

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