Difference between revisions of "YPL149W"

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'''Description of YPL149W:''' Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation<ref name='S000124888'>Hanada T, et al. (2007) The Atg12-Atg5 Conjugate Has a Novel E3-like Activity for Protein Lipidation in Autophagy. J Biol Chem 282(52):37298-302 {{SGDpaper|S000124888}} PMID 17986448</ref><ref name='S000069879'>Kuma A, et al. (2002) Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem 277(21):18619-25 {{SGDpaper|S000069879}} PMID 11897782</ref><ref name='S000051835'>Tsukada M and Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74 {{SGDpaper|S000051835}} PMID 8224160</ref><ref name='S000039962'>Mizushima N, et al. (1998) A protein conjugation system essential for autophagy. Nature 395(6700):395-8
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'''Description of YPL149W:''' Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation<ref name='S000039962'>Mizushima N, et al. (1998) A protein conjugation system essential for autophagy. Nature 395(6700):395-8 {{SGDpaper|S000039962}} PMID 9759731</ref><ref name='S000051835'>Tsukada M and Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74 {{SGDpaper|S000051835}} PMID 8224160</ref><ref name='S000069879'>Kuma A, et al. (2002) Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem 277(21):18619-25 {{SGDpaper|S000069879}} PMID 11897782</ref><ref name='S000124888'>Hanada T, et al. (2007) The Atg12-Atg5 Conjugate Has a Novel E3-like Activity for Protein Lipidation in Autophagy. J Biol Chem 282(52):37298-302
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  {{SGDpaper|S000124888}} PMID 17986448</ref>
 
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Revision as of 14:05, 31 March 2009

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Systematic name YPL149W
Gene name ATG5
Aliases APG5
Feature type ORF, Verified
Coordinates Chr XVI:271309..272193
Primary SGDID S000006070


Description of YPL149W: Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation[1][2][3][4]




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References

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  1. Mizushima N, et al. (1998) A protein conjugation system essential for autophagy. Nature 395(6700):395-8 SGD PMID 9759731
  2. Tsukada M and Ohsumi Y (1993) Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett 333(1-2):169-74 SGD PMID 8224160
  3. Kuma A, et al. (2002) Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem 277(21):18619-25 SGD PMID 11897782
  4. Hanada T, et al. (2007) The Atg12-Atg5 Conjugate Has a Novel E3-like Activity for Protein Lipidation in Autophagy. J Biol Chem 282(52):37298-302 SGD PMID 17986448

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